What if humans are an alien's experiment and we're all walking, talking computers. We regulate each other's nervous systems (which is actually true) to form a distributed computational system that grows and evolves on its own... e.g. by sharing past knowledge, specialization, and information distribution channels such as the Internet
What if we can build AI which controls arbitrary hardware?
What if our universe is an atom in a much larger universe, or atoms in our universe are each miniscule universes themselves?